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Evaluation

Submitted Presentation

SP-23 - Insights into the Endodontic Microbial Consortium

Thursday, April 18, 2024
2:00 PM – 2:45 PM PT
Location: 408 A
Earn 0.75 CE Credits

    Speaker(s)

  • Islam Ali, MDS, PhD

    Postdoctoral Scholar
    School of Dentistry, Oregon Health & Science University
    Portland, Oregon

    Disclosure(s): No financial relationships to disclose

    Slides Handouts

  • Prasanna Neelakantan, MDS, PhD

    Associate Professor and Director of Research (Endodontics)
    University of the Pacific Arthur A. Dugoni School of Dentistry
    San Francisco, California

    Disclosure(s): No financial relationships to disclose

    • Session Host(s)

  • Kazim Mirza, D.D.S., MDS., B.D.S.

    Dr
    University of the Pacific Arthur A. Dugoni School of Dentistry
    Irvine, California

    Disclosure(s): No financial relationships to disclose

Presentation Description/Abstract: Our knowledge on the need for root canal disinfection has improved tremendously over the past decades and yet, much about how endodontic microbiota are organized into sessile communities i.e. biofilms, remains largely unexplored. While we know that these biofilms and their by-products are the principal causes of apical periodontitis, knowledge is still nascent on their cellular and extracellular composition, epigenetic influences that drive compositional changes and most importantly, their functional profiles. We provided the first reports on the role of biological cues relevant to root canal environment and microbial genetics on biofilm matrix development. Driven by this evidence and our findings on inhibiting bacterial communication, the aim of this presentation is to provide an overview and in-depth analysis of the lifestyle, composition and functional characteristics of the root canal microbiome. This presentation will be instrumental in guiding the development of novel approaches against endodontic biofilms and prevention of their recovery.

Learning Objectives:

  • Characterize the key properties of biofilms that contribute to their tolerance to antimicrobial agents and disinfection strategies.
  • Discuss the current state of knowledge on microbial and functional profiles of the root canal microbiome.
  • Describe innovative approaches to suppress and/or eliminate endodontic biofilms.